The thyroid gland is an endocrine gland, The word endo-crine from Greek means internal secretion, This refers to the internal secretion of hormones in that case.

The thyroid gland is responsible for the production of thyroid hormones, thyroxine (T-4) which is later convertedTo thiodothyronine (T-3).

The hormone T3 (the biologically active derivative) is transmitted through the blood to every tissue in the body and in fact humans and other Mammalian creatures cannot

cannot be exsist without it.

 

These hormones are responsible, among other things, for the proper functioning of the muscles, heart, brain and other organs, as well as maintaining body temperature and energy utilization. 

woman's who suffer a lot from cold Body, even in the summer time, almost always have a Thyroid Problem in some way, Eeven if their TSH is balanced on blood Tests. in that case, The problem will be in the T-3 Conversion process.

The mode of action (physiology) of the thyroid gland when we are in complete health

 

Thyroid cells produce thyroxine from an amino acid called tyrosine and on tyrosine residues of a protein called thyroglobulin. Iodine coming from the diet is trapped in "iodine traps" and adheres to tyrosine residues. Simultaneously with the secretion of TSH from another endocrine gland called the pituitary gland.

Thyroid cells break down the connection between thyroglobulin and tyrosine and in this process thyroid hormones, thyroxine (T-4) and triiodothyronine (T-3) are formed and produst.

 

 triiodothyronine T-3 is the hormone that is biologically available to the body for energy utilization. Compared to thyroxine T-4, it contains 3 isomers of iodine, which allows it to enter body cells and perform intracellular metabolism. An enzyme called deiodinase is responsible for converting T-4 to T-3.

 

How does the thyroid gland know how much hormone it needs to produce?

A "loop" process based on negative feedback between the hypothalamus gland that secretes a hormone called TRH - Thyroid realising hormone which "commands" the pituitary gland to secrete TSH (the same hormone known from blood tests),  TSH - Thyroid Simulating Hormone.

This hormone (TSH) reflects with a limited degree of accuracy what is exact the status of the thyroid gland is in terms of the quality of function.

Why limited?

This Test Does not reflect Sub-clinical hypo-thyroid due to a problem in the converting processed of T-4 to T-3.

This process, which takes place mainly in the liver and kidneys by a dedicated enzyme, is the final expression of the hormonal loop as it releases T-3 freely and is available to all body cells.

 

 In some patients, the problem is not in the thyroid gland but in the conversion process. in that case the sympthoms can continue even during using thyroid medications.

In imbalance

 

In most cases, when there is an imbalance in TSH, the attending physician will seek further clarification. It is very important to insist on ruling out / confirming the presence of antibodies against the thyroid gland:

TPOab - Thyroid Proxidase Antibody :

Peroxidase is an enzyme used by the thyroid gland to produce its hormones by releasing iodine to bind tyrosine residues along with thyroglobin. When there is Hashimoto thyroiditis Disease, it means that this enzyme is attacked by the Immune system. Therefore, the test indicates the letters ab, which mean Anti-Bodies.

Iodine Mineral - Iodine:

The mineral iodine is a necessary mineral for the survival of all mammals. The sources of this mineral are varied and there are differences in the content of natural iodine in food depending on geography. In general, natural and reliable sources of iodine in the industrial age are organic seaweed, Atlantic salt, North Sea fishes, seafood, dairy products, eggs, and other animal foods. In developed countries, iodine is artificially added to grains and table salt in aim of preventing iodine deficiency.

 

A common clinical "mistake" of many therapists is to give iodine supplementation to patients with hypothyroidism in parallel with the presence of antibodies. as a treatment for hypothyroidism due to Hashimoto's thyroiditis . This often causes a significant increase in TSH and accelerates the autoimmune process.

These patients need to get this mineral from other sources that are not concentrated supplament , but rather from foods intact containing iodine as part of a complex of other nutrients such as all the foods mentioned in the above. This also applies to patients with overactive thyroid Graves disease , but the dose and form suitable to them under Their diagnosis.

Sometimes, despite the alleged balance in TSH in blood tests, there are clinical symptoms such as fatigue, weight gain, joint pain, feeling cold, etc. that indicate some functional problem in parallel with so-called balanced tests. In this case, it is our job to find the source of the imbalance. Statistically, 1 in 7 women is diagnosed with hypothyroidism, 1 in 4 suffers from latent hypothyroidism.

 

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